Forum 11/18/2004

“High Resolution CryoEM Imaging of Adenovirus”

Phoebe Stewart – Vanderbilt Univ.

Cryo electron microscopy imaging is an emerging technique in structural biology that is applicable to large macromolecular complexes, such as human adenovirus, virus/antibody and virus/receptor complexes.  Recent advances in cryo-microscopes, automation of data acquisition, and image processing on multi-processor computers, offer the potential of reaching near atomic resolution (3-5 Angstroms) by cryoEM methods.