Conformational flexibility of fatty acid synthase
Conformational flexibility of fatty acid synthase
Fatty acid synthase is composed of several catalytic domains that work in sequence. Asturias and colleagues use single-particle EM analysis of rat FAS to reveal the movements of the domains during the reaction cycle. The cover image of a flamenco dancer represents the complex motions of FAS in action (copyright Emanuele Ferrari, iStockphoto).
Edward J Brignole, Stuart Smith and Francisco J Asturias