Structures of the HIV Envelope trimer, a key AIDS molecule, modelled onto a viral membrane. These are the ﬁrst atomic-level structures of the tripartite HIV molecule — long considered one of the most difficult targets in structural biology and of great value for medical science. New data provide the most detailed picture yet of the AIDS-causing virus’s complex Envelope structure, including sites that future vaccines will try to mimic to elicit a protective human immune response. The structures were solved independently by x-ray crystallography and cryo-electron microscopy.
The image was rendered by Graham Johnson (UCSF).
Work that led to the 3D map was published in:
- Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA. Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science. 2013;342(6165):1477-83. PubMed
- Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science. 2013;342(6165):1484-90. PubMed